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I D Cancer Center
I D Cancer Center
From Diagnosis to Victory

  • Mental Cell Lymphoma

Mantle Cell Lymphoma Treatment | I D Cancer Center Lucknow

Overview

Mantle Cell Lymphoma (MCL) is a rare and aggressive type of non-Hodgkin lymphoma that begins in the “mantle zone” of B-cells (a part of the lymph nodes).
It often presents at an advanced stage but responds well to modern treatment when managed by an experienced oncology team.

At I D Cancer Center, we provide accurate diagnosis, advanced imaging, targeted therapies, immunotherapy, and precision radiotherapy, ensuring every patient receives personalized, evidence-based care.

What Causes Mantle Cell Lymphoma?

MCL is usually associated with a genetic change called:

  • t(11;14) translocation, leading to Cyclin D1 overexpression

Risk factors include:

  • Age above 55 years

  • Male gender

  • Family history of lymphoma

  • Weakened immunity

  • Genetic susceptibility

It is not hereditary and cannot spread from one person to another.

Common Signs & Symptoms

Symptoms may develop gradually or rapidly depending on the disease pattern.

General Symptoms

  • Persistent fever, night sweats, or unexplained weight loss (“B” symptoms)

  • Fatigue

  • Loss of appetite

Lymph Node Symptoms

  • Painless swelling in neck, armpits, or groin

Digestive System Symptoms (very common in MCL)

  • Abdominal discomfort

  • Indigestion

  • Bloating

  • Changes in bowel habits

  • Enlarged spleen

Other Symptoms

  • Frequent infections

  • Anemia or low blood counts

If these symptoms persist, evaluation by a lymphoma specialist is essential.

Diagnosis at I D Cancer Center

Accurate diagnosis is critical because MCL can mimic other lymphomas. We use:

  • Complete clinical evaluation

  • Blood tests & LDH levels

  • Excisional or core biopsy

  • Immunohistochemistry (Cyclin D1, SOX11)

  • Flow cytometry

  • PET-CT scan

  • Bone marrow biopsy

  • Molecular testing to classify aggressive vs. indolent MCL

Our multidisciplinary team reviews every case to plan the most suitable treatment.

Treatment Options

Treatment depends on the stage, patient age, fitness, and aggressiveness of the disease.

1. Chemotherapy

Often the first step in treatment:

  • R-CHOP

  • Hyper-CVAD

  • BR (Bendamustine + Rituximab)

  • Cytarabine-based regimens (for younger patients)

2. Immunotherapy

Monoclonal antibodies significantly improve outcomes:

  • Rituximab (commonly used)

  • Obinutuzumab (selected cases)

3. Targeted Therapy

Modern treatments that specifically block cancer-cell growth:

  • Ibrutinib, Acalabrutinib, Zanubrutinib (BTK inhibitors)

  • Lenalidomide

  • Bortezomib

These are extremely effective for relapsed or refractory MCL.

4. Radiation Therapy

Used for:

  • Localized disease

  • Symptom control

  • Bulky nodes

  • Patients unfit for systemic therapy
    At I D Cancer Center, we offer IMRT, IGRT, and VMAT for safe and precise delivery.

5. Stem Cell Transplant (selected cases)

Autologous transplant may be offered to younger, fit patients for long-term disease control.

6. Supportive Care

  • Infection prevention

  • Nutritional guidance

  • Counselling & psychological support

  • Management of low blood counts

Follow-Up & Long-Term Care

MCL requires continuous monitoring. We provide:

  • Regular PET-CT/CT scans

  • Blood tests and immune function evaluation

  • Side-effect management

  • Vaccination guidance

  • Long-term survivorship planning

Our aim is to ensure patients maintain strength, confidence, and quality of life.

Why Choose I D Cancer Center?

  • Expert oncology team led by Dr. Sunil Kumar

  • Advanced PET-CT–based evaluation

  • Precision radiotherapy (IMRT, IGRT, VMAT)

  • Access to modern targeted & immunotherapy drugs

  • Multidisciplinary tumour board

  • Compassionate, patient-centric environment

  • Convenient location in Sushant Golf City, Lucknow