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  • Lymphoma

Lymphoma Treatment | I D Cancer Center Lucknow

Overview

Lymphoma is a cancer of the lymphatic system, which forms a crucial part of the body's immune defense. It affects lymph nodes, spleen, bone marrow, thymus, and other lymphatic tissues.

Lymphoma is one of the most treatable cancers, especially when diagnosed early. Many patients achieve long-term remission with modern therapies such as chemotherapy, targeted therapy, immunotherapy, radiotherapy, and advanced imaging-based treatment planning.

At I D Cancer Center, we offer comprehensive care for all lymphoma types with precision diagnostics, PET-CT staging, molecular profiling, and evidence-based treatment plans led by expert oncologists.


Types of Lymphoma

Lymphomas are broadly classified into two categories:

1. Hodgkin Lymphoma (HL)

Characterized by the presence of Reed–Sternberg cells.
Highly curable with timely treatment.

2. Non-Hodgkin Lymphoma (NHL)

A diverse group with 60+ subtypes, including:

  • Diffuse Large B-Cell Lymphoma (DLBCL)

  • Follicular Lymphoma

  • Mantle Cell Lymphoma

  • Burkitt Lymphoma

  • Peripheral T-Cell Lymphoma

  • Marginal Zone Lymphoma

Each type behaves differently and requires tailored treatment.


Causes & Risk Factors

Possible Causes

  • Genetic mutations

  • Weakened immune system

  • Exposure to toxins or pesticides

  • Autoimmune disorders

  • Viral infections (EBV, HIV)

Risk Factors

  • Older age

  • Male gender

  • Family history

  • Previous chemotherapy or radiation

  • Chronic infections

Lymphoma is not contagious.


Symptoms of Lymphoma

Patients may experience:

Common Symptoms

  • Painless swelling of lymph nodes (neck, armpit, groin)

  • Persistent fever

  • Night sweats

  • Unexplained weight loss

  • Fatigue

  • Persistent cough or breathlessness

  • Abdominal pain or fullness

  • Itching without rash

These symptoms are often mistaken for infections—early evaluation is essential.


Diagnosis at I D Cancer Center

We follow NCCN/ESMO guidelines for accurate diagnosis and staging.

Clinical Assessment

  • Detailed physical examination

  • Symptom evaluation

Laboratory Tests

  • Complete blood count (CBC)

  • LDH levels

  • Viral markers

  • Immunoglobulin levels

Imaging

  • PET-CT Scan (gold standard for lymphoma staging)

  • CT Scan

  • Ultrasound

Tissue Diagnosis

  • Excisional lymph node biopsy

  • Needle biopsy (in selected cases)

  • Bone marrow biopsy for staging

Immunohistochemistry & Molecular Testing

Helps identify exact lymphoma subtype, including:

  • CD markers

  • Ki-67 proliferation index

  • Genetic mutations and rearrangements (BCL-2, BCL-6, MYC)

Accurate classification guides precise treatment.


Treatment Options

Treatment depends on lymphoma subtype, stage, age, symptoms, and overall health.


1. Chemotherapy

Most lymphomas respond extremely well to chemotherapy.

Common regimens:

  • ABVD (for Hodgkin Lymphoma)

  • CHOP / R-CHOP (for DLBCL)

  • Bendamustine-based regimens

  • Intensive regimens for high-grade lymphomas


2. Targeted Therapy

Designed to attack cancer-specific pathways.

Examples:

  • Rituximab (CD20-targeted)

  • Ibrutinib / Acalabrutinib (BTK inhibitors)

  • Venetoclax

  • Lenalidomide


3. Immunotherapy

Activates the immune system to fight cancer:

  • Checkpoint inhibitors (Pembrolizumab, Nivolumab)

  • CAR-T therapy (in selected relapsed cases)


4. Radiation Therapy

At I D Cancer Center, radiotherapy is delivered using:

  • IMRT (Intensity Modulated Radiotherapy)

  • IGRT (Image Guided Radiotherapy)

  • VMAT (Volumetric Modulated Arc Therapy)

Used for:

  • Early-stage HL/NHL

  • Residual disease after chemotherapy

  • Symptom relief (pain, compression, swelling)


5. Stem Cell Transplant

Used for relapsed or high-risk lymphoma:

  • Autologous transplant

  • Allogeneic transplant

We coordinate with leading national transplant centers while providing complete pre- and post-care.


6. Supportive Care

Essential throughout treatment:

  • Management of infections

  • Nutritional support

  • Blood transfusions (if needed)

  • Pain management

  • Psychological support


Living with Lymphoma

We offer complete survivorship support:

  • Routine follow-ups

  • PET-CT monitoring

  • Lifestyle, diet & immunity guidance

  • Emotional counselling

  • Management of long-term side effects

Many patients return to normal life after treatment.


Why Choose I D Cancer Center?

  • Expert care led by Dr. Sunil Kumar

  • Advanced imaging: PET-CT, CT, Ultrasound

  • Full lymphoma workup (biopsy, IHC, molecular tests)

  • Modern chemotherapy suites

  • Precision radiotherapy (IMRT/IGRT/VMAT)

  • Multidisciplinary tumour board

  • Friendly and patient-centered environment

  • Convenient location in Sushant Golf City, Lucknow