CAR-T Cell Therapy in India | Evaluation at I D Cancer Centre
Revolutionary Personalized Immunotherapy for Blood Cancers
CAR-T Cell Therapy (Chimeric Antigen Receptor T-Cell Therapy) is one of the most advanced cancer treatments available today. It uses a patient’s own immune cells, re-engineers them in the laboratory, and turns them into powerful cancer-killing cells.
What Is CAR-T Cell Therapy?
CAR-T therapy is an advanced immunotherapy where doctors:
Collect T-cells from the patient’s blood
Genetically modify these cells in a special lab
Add a receptor (CAR) to help T-cells identify cancer
Multiply these modified cells
Infuse them back into the patient
Modified T-cells now find and destroy cancer cells
CAR-T therapy is an advanced immunotherapy where doctors:
Collect T-cells from the patient’s blood
Genetically modify these cells in a special lab
Add a receptor (CAR) to help T-cells identify cancer
Multiply these modified cells
Infuse them back into the patient
Modified T-cells now find and destroy cancer cells
⭐ In simple words:
CAR-T therapy trains your immune system to hunt and kill cancer cells.
CAR-T therapy trains your immune system to hunt and kill cancer cells.
⭐ Why CAR-T Cell Therapy Is Needed
CAR-T therapy is used when:
CAR-T therapy is used when:
1. Cancer Does Not Respond to Standard Treatment
Especially when chemotherapy or targeted therapy stops working.
Especially when chemotherapy or targeted therapy stops working.
2. Cancer Comes Back After Treatment
CAR-T is highly effective for relapsed or refractory cancers.
CAR-T is highly effective for relapsed or refractory cancers.
3. A More Personalized, Precise Treatment Is Required
Because CAR-T uses the patient’s own cells, it is uniquely tailored.
Because CAR-T uses the patient’s own cells, it is uniquely tailored.
⭐ Which Cancers Are Treated with CAR-T?
CAR-T is mainly used for blood cancers, especially:
CAR-T is mainly used for blood cancers, especially:
✔ B-cell Acute Lymphoblastic Leukemia (ALL)
Very effective in children & young adults.
Very effective in children & young adults.
✔ B-cell Lymphomas
✔ Mantle Cell Lymphoma
✔ Multiple Myeloma
(BCMA-targeted CAR-T)
Many clinical trials are also evaluating CAR-T for solid tumors.
(BCMA-targeted CAR-T)
Many clinical trials are also evaluating CAR-T for solid tumors.
⭐ How CAR-T Cell Therapy Works
CAR-T is a multi-step, personalized process:
CAR-T is a multi-step, personalized process:
1. Patient Evaluation
Oncologist assesses eligibility and performs staging tests.
Oncologist assesses eligibility and performs staging tests.
2. T-Cell Collection (Leukapheresis)
Blood is drawn through a special machine that separates T-cells.
Blood is drawn through a special machine that separates T-cells.
3. Cell Engineering in Lab
T-cells are genetically modified to develop “CAR receptors”.
T-cells are genetically modified to develop “CAR receptors”.
4. Cell Expansion
Millions of CAR-T cells are produced.
Millions of CAR-T cells are produced.
5. Conditioning Chemotherapy
A short chemotherapy course prepares the body.
A short chemotherapy course prepares the body.
6. CAR-T Cell Infusion
Modified cells are infused like a blood transfusion.
Modified cells are infused like a blood transfusion.
7. Monitoring & Recovery
Patient is monitored for immune response and side effects.
Patient is monitored for immune response and side effects.
⭐ Benefits of CAR-T Cell Therapy
✔ High Success Rates
Many patients achieve long-term remission.
Many patients achieve long-term remission.
✔ Highly Personalized Treatment
Uses the patient’s own immune cells.
Uses the patient’s own immune cells.
✔ One-Time Treatment
Often a single infusion is sufficient.
Often a single infusion is sufficient.
✔ Works Even When Cancer Resists Other Therapies
✔ No Surgery, No Radiation
⭐ Possible Side Effects of CAR-T Therapy
CAR-T is powerful, so monitoring is essential.
CAR-T is powerful, so monitoring is essential.
Common temporary side effects:
Cytokine Release Syndrome (fever, chills)
Fatigue
Low blood pressure (in some cases)
Short-term neurological symptoms (confusion, headache)
Lowered blood counts
These reactions are manageable in specialized centers.
Cytokine Release Syndrome (fever, chills)
Fatigue
Low blood pressure (in some cases)
Short-term neurological symptoms (confusion, headache)
Lowered blood counts
These reactions are manageable in specialized centers.
Conclusion
CAR-T Cell Therapy is one of the most revolutionary advancements in cancer treatment. It offers new hope to patients whose cancers have not responded to conventional therapies.
CAR-T Cell Therapy is one of the most revolutionary advancements in cancer treatment. It offers new hope to patients whose cancers have not responded to conventional therapies.
