Acute Myeloid Leukemia (AML) Treatment in Lucknow | Hemato-Oncology Care | I D Cancer Center
Overview
Acute Myeloid Leukemia (AML) is a fast-growing cancer of the bone marrow and blood, where immature white blood cells (myeloblasts) multiply rapidly and crowd out normal blood cells. AML requires urgent diagnosis and specialized treatment, as timely intervention significantly improves outcomes.
At I D Cancer Center, we offer comprehensive diagnostic facilities, expert oncologists, and modern chemotherapy and targeted therapy protocols to manage AML effectively.
Acute Myeloid Leukemia (AML) is a fast-growing cancer of the bone marrow and blood, where immature white blood cells (myeloblasts) multiply rapidly and crowd out normal blood cells. AML requires urgent diagnosis and specialized treatment, as timely intervention significantly improves outcomes.
At I D Cancer Center, we offer comprehensive diagnostic facilities, expert oncologists, and modern chemotherapy and targeted therapy protocols to manage AML effectively.
How AML Develops
AML begins in the bone marrow when genetic mutations cause immature cells to grow uncontrollably. These abnormal cells enter the blood and interfere with:
Red blood cell production → anemia
White blood cell function → infections
Platelet formation → bleeding/bruising
AML begins in the bone marrow when genetic mutations cause immature cells to grow uncontrollably. These abnormal cells enter the blood and interfere with:
Red blood cell production → anemia
White blood cell function → infections
Platelet formation → bleeding/bruising
Common Symptoms
AML symptoms appear quickly and may include:
AML symptoms appear quickly and may include:
Blood-Related Symptoms
Fatigue, weakness, or breathlessness
Pale skin (anemia)
Frequent infections or fever
Easy bruising or bleeding
Nosebleeds / bleeding gums
Fatigue, weakness, or breathlessness
Pale skin (anemia)
Frequent infections or fever
Easy bruising or bleeding
Nosebleeds / bleeding gums
General Symptoms
Bone or joint pain
Loss of appetite
Weight loss
Night sweats
Bone or joint pain
Loss of appetite
Weight loss
Night sweats
Less Common Symptoms
Swollen lymph nodes
Enlarged liver or spleen
Skin rashes or spots (leukemia cutis)
Seek medical attention immediately if symptoms appear suddenly.
Swollen lymph nodes
Enlarged liver or spleen
Skin rashes or spots (leukemia cutis)
Seek medical attention immediately if symptoms appear suddenly.
Risk Factors
Most people with AML have no clear risk factor, but some conditions increase risk:
Older age (>60 years)
Previous chemotherapy or radiotherapy
Smoking
Exposure to benzene or chemicals
Genetic disorders (e.g., Down syndrome)
Blood disorders: MDS, MPN
Family history of leukemia
Most people with AML have no clear risk factor, but some conditions increase risk:
Older age (>60 years)
Previous chemotherapy or radiotherapy
Smoking
Exposure to benzene or chemicals
Genetic disorders (e.g., Down syndrome)
Blood disorders: MDS, MPN
Family history of leukemia
Diagnosis at I D Cancer Center
We provide complete hemato-oncology workup:
We provide complete hemato-oncology workup:
1. Blood Tests
Complete blood count (CBC)
Peripheral smear
LDH and other markers
Complete blood count (CBC)
Peripheral smear
LDH and other markers
2. Bone Marrow Tests
Bone marrow aspiration & biopsy
Morphology and blast percentage
Cytogenetics (karyotyping)
Flow cytometry
Molecular analysis (FLT3, NPM1, CEBPA, etc.)
Bone marrow aspiration & biopsy
Morphology and blast percentage
Cytogenetics (karyotyping)
Flow cytometry
Molecular analysis (FLT3, NPM1, CEBPA, etc.)
3. Imaging (when needed)
Ultrasound
Chest X-ray
CT scan for complications
Our Multidisciplinary Tumor Board reviews each case to create a personalized plan.
Ultrasound
Chest X-ray
CT scan for complications
Our Multidisciplinary Tumor Board reviews each case to create a personalized plan.
Treatment Options
AML requires urgent, structured therapy in phases:
AML requires urgent, structured therapy in phases:
1. Induction Chemotherapy
Aim: Achieve complete remission by reducing leukemia blasts.
Common regimen:
“7+3” protocol (Cytarabine + Anthracycline)
Aim: Achieve complete remission by reducing leukemia blasts.
Common regimen:
“7+3” protocol (Cytarabine + Anthracycline)
2. Consolidation Therapy
High-dose cytarabine
Combination chemotherapy
3. Targeted Therapy
Based on mutation profile:
FLT3 inhibitors
IDH1/IDH2 inhibitors
- BCL-2 inhibitors (Venetoclax)Improves outcomes in elderly or high-risk patients.
4. Stem Cell Transplant (SCT)
Recommended for:
High-risk AML
Relapsed disease
- Poor prognostic markersOffers the best chance of long-term cure in select patients.
5. Supportive & Palliative Care
Critical part of AML treatment:
Infection control
Blood/platelet transfusions
Growth factors
Nutritional support
Management of treatment side effects
Critical part of AML treatment:
Infection control
Blood/platelet transfusions
Growth factors
Nutritional support
Management of treatment side effects
Prognosis
AML prognosis depends on:
Age
Cytogenetic/molecular profile
Response to induction therapy
Overall health
With modern protocols, many patients achieve remission and long-term survival.
AML prognosis depends on:
Age
Cytogenetic/molecular profile
Response to induction therapy
Overall health
With modern protocols, many patients achieve remission and long-term survival.
